My drawing for the cover of "Immunity" has been published
My drawing for the cover of the latest issue of "Immunity" has been published. The original version was not used because the layer containing the gradients has been removed.
Immunity, Volume 33, Issue 5, 804-816, 18 November 2010 10.1016/j.immuni.2010.10.015
Abstract::
The enteroinvasive bacterium Shigella flexneri uses multiple secreted effector proteins to downregulate interleukin-8 (IL-8) expression in infected epithelial cells. Yet, massive IL-8 secretion is observed in Shigellosis. Here we report a host mechanism of cell-cell communication that circumvents the effector proteins and strongly amplifies IL-8 expression during bacterial infection. By monitoring proinflammatory signals at the single-cell level, we found that the activation of the transcription factor NF-κB and the MAP kinases JNK, ERK, and p38 rapidly propagated from infected to uninfected adjacent cells, leading to IL-8 production by uninfected bystander cells. Bystander IL-8 production was also observed during Listeria monocytogenes and Salmonella typhimurium infection. This response could be triggered by recognition of peptidoglycan and is mediated by gap junctions. Thus, we have identified a mechanism of cell-cell communication that amplifies innate immunity against bacterial infection by rapidly spreading proinflammatory signals via gap junctions to yet uninfected cells.
That's it
Pierre
4 comments:
Fantastic drawing, Pierre! Congratulations!
well done sir, an impressive drawing
You have a real knack to drawing and Photoshop. Hats off little penguin !
Congratulations! It's a great drawing!
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