24 November 2010

My drawing for the cover of "Immunity" has been published

My drawing for the cover of the latest issue of "Immunity" has been published. The original version was not used because the layer containing the gradients has been removed.

. My drawing illustrates the paper by Kasper & al.: Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection
Immunity, Volume 33, Issue 5, 804-816, 18 November 2010 10.1016/j.immuni.2010.10.015
The enteroinvasive bacterium Shigella flexneri uses multiple secreted effector proteins to downregulate interleukin-8 (IL-8) expression in infected epithelial cells. Yet, massive IL-8 secretion is observed in Shigellosis. Here we report a host mechanism of cell-cell communication that circumvents the effector proteins and strongly amplifies IL-8 expression during bacterial infection. By monitoring proinflammatory signals at the single-cell level, we found that the activation of the transcription factor NF-κB and the MAP kinases JNK, ERK, and p38 rapidly propagated from infected to uninfected adjacent cells, leading to IL-8 production by uninfected bystander cells. Bystander IL-8 production was also observed during Listeria monocytogenes and Salmonella typhimurium infection. This response could be triggered by recognition of peptidoglycan and is mediated by gap junctions. Thus, we have identified a mechanism of cell-cell communication that amplifies innate immunity against bacterial infection by rapidly spreading proinflammatory signals via gap junctions to yet uninfected cells.

That's it



Berci Meskó said...

Fantastic drawing, Pierre! Congratulations!

Anonymous said...

well done sir, an impressive drawing

Insolite Movies said...

You have a real knack to drawing and Photoshop. Hats off little penguin !

bioinformatico said...

Congratulations! It's a great drawing!